I am a physical chemist with expertise in the field of colloidal science, skilled in experiments, theory and simulations to solve pharmaceutical problems – from small molecules to macromolecules like mRNA.

I have been working at AstraZeneca for over 25 years on gastrointestinal absorption, oral vaccines, molecular simulations, nanop文章 systems of poorly soluble drugs and 更多 recently, on lipid nanop文章s and exosomes incorporating nucleic acids.

I received my PhD at Chalmers University of Technology in 1993. In 2007, I became an adjunct Professor at the Department of Chemistry and Molecular Biology, University of Gothenburg, which enhances my interaction with the academic community.


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2018

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2017

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2016

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Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation. S10外围

Cao E,  Lindgren A, Martinsson S,  Hu LJ, Lindfors L, Sigfridsson K, Skantze U, Michaelsson E, Trevaskis NL, Porter CJH. Journal of Controlled Release, (2019), 296: 29. Publication link

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles.S10外围

Arteta MY, Kjellman T, Bartesaghi S, Wallin S, Wu X, Kvistc AJ, Dabkowska A, Székely N, Radulescu A, Bergenholtz J, Lindfors L. Proceedings of the National Academy of Sciences (2018), 115: E3351. Publication link.

Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells.S10外围

Sigfridsson K, Skantze U, Skantze P, Johansson S, Grant I,  Smedsrød B, Fuglesteg B, Elvevold K, Lindfors L. International Journal of Pharmaceutics (2017), 518: 29.  Publication link.

Nanocrystal formulations of a poorly soluble drug. 2. Evaluation of nanocrystal liver uptake and distribution after intravenous administration to mice. S10外围

Sigfridsson K, Skantze P, Skantze U, Svensson L,  Löfgren L, Nordell P, Michaelsson E, Smedsrød B, Fuglesteg B, Elvevold K, Lindfors L. International Journal of Pharmaceutics (2017), 524: 248. Publication link.

Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction. S10外围

Krishna Dasa SS, Suzuki R, Gutknecht M, Brinton LT, Tian Y, Michaelsson E, Lindfors L,  Klibanov AL, French BA, Kelly KA. Journal of Controlled Release (2015), 220: 556.  Publication link.

Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered.S10外围

Anwar J, Khan S, Lindfors L. Angewandte Chemie (2014), 127: 14894. Publication link.

Nucleation and crystal growth in supersaturated solutions of a model drugS10外围

Lindfors L, Forssén S, Westergren J, Olsson U. Journal of Colloid and Interface Science (2008), 325: 404. Publication link.

Amorphous drug nanosuspensions.1.Inhibition of Ostwald ripeningS10外围

Lindfors L, Skantze P, Skantze U, Rasmusson M, Zackrisson A, Olsson U. Langmuir (2007), 22: 906. Publication link.

Amorphous drug nanosuspensions.2. Experimental determination of bulk monomer concentrationsS10外围

Lindfors L, Forssén S, Skantze P, Skantze U, Zackrisson A, Olsson U. Langmuir (2007), 22: 911. Publication link.

Amorphous drug nanosuspensions.3. Particle dissolution and crystal growth S10外围

Lindfors L, Skantze P, Skantze U, Westergren J, Olsson U. Langmuir (2007), 23: 9866.  Publication link.